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Welcome to WntTalks

Welcome to WntTalks


With a two-year hiatus for in-person Wnt meetings due to the SARS-CoV-2 pandemic, we feel it is important to provide an opportunity to get the Wnt community together and provide a platform for trainees and Wnt researchers to present their work.

After a successful Season 1 and Season 2, WntTalks returns in full force for Season 3 on February 10 2022. The organizing committee is scouting Twitter and Biorxiv for the latest stories – please feel free to (self)nominate and submit your tips (and if possible a title and abstract) to

To be able to keep the frequency of talks, we are looking for volunteers to (co-)chair these sessions in the upcoming season. If you know how to set up and run a zoom meeting and would like to help us out, please also contact

The setup is similar in philosophy to the early Wnt meetings – prioritizing trainees and early career scientists presenting their work. There will be two talks per session, each talk allotted a total of 30 minutes (20 min talk and 10 min discussion).

Importantly, to accommodate the international nature of the community, each speaker presents TWICE within a 24-hour period (see schedule and time zones below). This allows an audience from Europe, Americas and Asia/Australia to join one or the other talk. This format was highly successful and appreciated during Season 1 and we thank all our speakers and hosts for taking the extra effort to keep this format up and running.

After the talks, participants are invited to mingle at our dedicated Wnt Talks space, For season 3, we will keep spatial chat open for 30 minutes right after the talks. Think of it as a virtual coffee break before you go back to work – and also come join us if you don’t know anyone yet. We are always happy to meet new colleagues and talk about anything Wnt related – so don’t hesitate to join us!


Session #1 (UTC time)ZOOM LINK Session #1Session #2 (UTC time)ZOOM LINK Session #2Speaker 1TitleSpeaker 2Title

Arial Zeng
Babita Madan
Thursday 10 Feb 2022, 9:00 11 Feb 2022,
01:00 Jia, Tsinghua University, ChinaTCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through a transcriptional repression mechansismMasanobu Oshima, Kanazawa University, JapanCharacterization of RNF43 frameshift mutations that drive Wnt ligand and R-spondin dependent colon cancer

chair/co-chair: Karl Willert, Vidhya Munnamalai (session 1) and Marian Waterman (session 2)
Thursday March 3, 17:00 March 4, 01:00 Masri, UC Irvine, USAWnt signaling and Colorectal Cancer: New links with the Circadian Clock

Andy Yang, University of Toronto, CanadaMaking dopaminergic neurons with designer Wnt agonists


Renée van Amerongen
Thursday, March 24, 08:00, March 24, 16:00 Sun, Rawlins lab, Gurdon Institute, Cambridge, UKSOX9 primes human fetal lung tip progenitors to receive WNT and RTK signalsDominic Bernkopf, Friedrich-Alexander University Erlangen-Nürnberg,
Galphai2-induced Conductin/Axin2 condensates inhibit Wnt/beta-catenin signaling and suppress cancer growth





Session #1 (UTC time)ZOOM LINK Session #1Session #2 (UTC time)ZOOM LINK Session #2Speaker 1TitleSpeaker 2Title

Marian Waterman
Vidhya Munnamalai
Thursday September 16 2021, 15:00 September 17 2021, 0:00 Nusse, Stanford UniversityIf Wnt is a proliferative signal, why do cells need other signals in addition to Wnt to enter the cell cycle ?Ben Myers, Asst Prof, U. Utah“Pseudosubstrate Inhibition: A Shared Biochemical Mechanism underlying Hedgehog and Wnt Signal Transduction?”

Liz Vincan
Osvaldo Contreras
Thursday October 7 2021, 8:00 October 7 2021, 23:00 David Virshup,
Duke-NUS, Singapore
Lessons from PORCN inhibitors


Postdoc in A. Tups lab, University of 
Otago, New Zealand
The canonical Wnt pathway as a central 
mediator of glucose homeostasis in zebrafish


Claudio Cantù
Nuray Gunduz
Thursday October 28 2021, 7:00 October 28 2021, 16:00 Giebel, PhD student with Dr. Sergio Acebrón, 
Heidelberg University, Germany
Regulation of Wnt signalling 
by the deubiquitinase USP42 in adult stem cells and cancer
Bassem Hassan, Paris Brain Institute/INSERM, FranceThe Amyloid Precursor Protein 
is a conserved Wnt receptor

Marian Waterman
Henry Ho
Thursday November 18 2021, 15:00 November 19 2021, 00:00 Nabhan, postdoctoral fellow, GenentechDissecting and manipulating lung alveolar regeneration with frizzled agonistsSathya Srinivasan,
post-doctoral fellow with Henry Ho,
University of California, Davis
Wnt5a-Ror signaling regulates cell migration and contractility via RhoA-Myosin-Actin axis

David Virshup
Liz Vincan
Thursday December 9 2021, 8:00 332926Thursday December 9 2021, 23:00  passcode 892651Yiwei Li, Huazhong University of Science and Technology, ChinaMolecular crowding as a mechanoregulator of intestinal organoid growth via stabilizing LRP6 signalosomeKristen S. Barratt, PD with Ruth Arkell, ANU, Canberra, AustraliaZIC3 Inhibition of Canonical WNT Signalling Controls Endoderm Formation To Ensure Left Right Heart Development

Claudio Cantù
Nuray Gunduz
Thursday January 13 2022, 8:00 January 13 2022, 17:00
Dustin Flanagan, postdoc with Owen Sansom, CRUK
Beatson Institute, Glasgow, UK
Notum is deployed by Apc-mutant cells to rule
the intestinal crypt
Yorick van de Grift, PhD student with Renée van
Amerongen, University of Amsterdam, the Netherlands
A conserved distal chromatin hub controls
Wnt4 gene expression in the mammary gland


Spring Session #1 (UTC time)ZOOM LINK Session #1Spring Session #2 (UTC time)ZOOM LINK Session #2Speaker 1TitleSpeaker 2Title
Thursday, April 8, 2021, 8:00:00 AMThursday, April 8, 2021, 11:00:00 PMJia Yu, (PDF, David Virshup lab)“Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion”Kenta Kawasaki, (PDF, Toshi Sato lab)“Wnt independency and morphology of colon tumors”
Thursday, April 22, 2021, 4:00:00 PMFriday, April 23, 2021, 12:00:00 AMShreyasi Mukherjee (Graduate student, Zorn lab, Cincinnati Children’s Hospital Medical Center,)SOX transcription factors direct TCF-independent Wnt/ß-catenin transcription.

Renee Conway, graduate student (Spence lab, University of Michigan)“R-SPONDIN2+ Mesenchymal Cells Form the Bud Tip Progenitor Niche During Human Lung 

Thursday, May 6, 2021, 9:00:00 AMThursday, May 6, 2021, 4:00:00 PMKarol Kaiser
Bryja lab,
Brno, Czech Republic

current position: postdoc
Doetsch lab in Basel

Title: Meis1-Wnt5a axis – The story of two choroid plexusesMartti Maimets
PDF, Jensen lab, BRIC and DanStem, University of Copenhagen, Denmark

Title: Mesenchymal-epithelial crosstalk shapes regional differences in the intestine via Wnt and Shh signalling
Thursday, May 20, 2021, 8:00:00 AMThursday, May 20, 2021, 11:00:00 PMKazuhiro Murakami, Kanazawa University (Nick Barker
A Genome-Scale CRISPR screen reveals
novel factors regulating Wnt-
dependent renewal of mouse gastric
epithelial cells.
Chunhua Wan, Monash University
(Ron Firestein lab)
“TOPFLASH does not light the way – Endogenous Wnt/β-catenin reporters identify therapeutic targets for Colorectal Cancer”.
Thursday, June 3, 2021, 4:00:00 PMFriday, June 4, 2021, 12:00:00 AMMyan Do, UCSD (Karl Willert lab) “A FZD7-specific antibody-drug conjugate induces solid tumor regression in preclinical models”.Vidhya Munnamalai 
Assistant Professor, 
The Jackson Laboratory 
“Making sense from Incoherence: How the Wnt pathway segregates domains in the
cochlea through an incoherent feedforward circuit.”
Thursday, June 17, 2021, 9:00:00 AMThursday, June 17, 2021, 4:00:00 PMTiemei Li,
Postdoctoral fellow,
Bienz Lab
Cambridge UK
A tripartite complex between Axin and GSK3β bound to the cytoplasmic tail of LRP6 in Wnt signalosomesHazel Quinn, Walter Birchmeier lab, current affiliation
Post-doctoral researcher
Brisken Laboratory
Lausanne, Switzerland
YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal-like Breast Cancer