Welcome to WntTalks
Welcome to WntTalks
@TalksWnt
With a two-year hiatus for in-person Wnt meetings due to the SARS-CoV-2 pandemic, we feel it is important to provide an opportunity to get the Wnt community together and provide a platform for trainees and Wnt researchers to present their work.
After a successful Season 1 and Season 2, WntTalks returns in full force for Season 3 on February 10 2022. The organizing committee is scouting Twitter and Biorxiv for the latest stories – please feel free to (self)nominate and submit your tips (and if possible a title and abstract) to wnttalks@gmail.com.
To be able to keep the frequency of talks, we are looking for volunteers to (co-)chair these sessions in the upcoming season. If you know how to set up and run a zoom meeting and would like to help us out, please also contact wnttalks@gmail.com.
The setup is similar in philosophy to the early Wnt meetings – prioritizing trainees and early career scientists presenting their work. There will be two talks per session, each talk allotted a total of 30 minutes (20 min talk and 10 min discussion).
Importantly, to accommodate the international nature of the community, each speaker presents TWICE within a 24-hour period (see schedule and time zones below). This allows an audience from Europe, Americas and Asia/Australia to join one or the other talk. This format was highly successful and appreciated during Season 1 and we thank all our speakers and hosts for taking the extra effort to keep this format up and running.
After the talks, participants are invited to mingle at our dedicated Wnt Talks space,
https://spatial.chat/s/WntTalks. For season 3, we will keep spatial chat open for 30 minutes right after the talks. Think of it as a virtual coffee break before you go back to work – and also come join us if you don’t know anyone yet. We are always happy to meet new colleagues and talk about anything Wnt related – so don’t hesitate to join us!
SCHEDULE S03
| Season/ episode | Session #1 (UTC time) | ZOOM LINK Session #1 | Session #2 (UTC time) | ZOOM LINK Session #2 | Speaker 1 | Title | Speaker 2 | Title |
|---|---|---|---|---|---|---|---|---|
| S03E01 chair/co-chair: Arial Zeng Babita Madan | Thursday 10 Feb 2022, 9:00 | https://nus-sg.zoom.us/j/82374142692?pwd=dnJaTEtRUlJlajBkRU5RdGN1TWdPZz09 | Friday 11 Feb 2022, 01:00 | https://nus-sg.zoom.us/j/87449924731?pwd=MHB0QlhqRFRaYzFZS2dqSklGVFhwUT09 | Yichang Jia, Tsinghua University, China | TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through a transcriptional repression mechansism | Masanobu Oshima, Kanazawa University, Japan | Characterization of RNF43 frameshift mutations that drive Wnt ligand and R-spondin dependent colon cancer |
| S03E02 chair/co-chair: Karl Willert, Vidhya Munnamalai (session 1) and Marian Waterman (session 2) | Thursday March 3, 17:00 | https://uci.zoom.us/j/7760522094 | Friday March 4, 01:00 | https://uci.zoom.us/j/7760522094 | Selma Masri, UC Irvine, USA | Wnt signaling and Colorectal Cancer: New links with the Circadian Clock | Andy Yang, University of Toronto, Canada | Making dopaminergic neurons with designer Wnt agonists |
| S03E03 chair/co-chair: Renée van Amerongen | Thursday, March 24, 08:00 | https://uva-live.zoom.us/j/88439446521 | Thursday, March 24, 16:00 | https://uva-live.zoom.us/j/82118731683 | Dawei Sun, Rawlins lab, Gurdon Institute, Cambridge, UK | SOX9 primes human fetal lung tip progenitors to receive WNT and RTK signals | Dominic Bernkopf, Friedrich-Alexander University Erlangen-Nürnberg, Germany | Galphai2-induced Conductin/Axin2 condensates inhibit Wnt/beta-catenin signaling and suppress cancer growth |
| S03E04 chair/co-chair: | ||||||||
| S03E05 chair/co-chair: | ||||||||
| S03E06 chair/co-chair: |
SCHEDULE S02
| Season/ episode | Session #1 (UTC time) | ZOOM LINK Session #1 | Session #2 (UTC time) | ZOOM LINK Session #2 | Speaker 1 | Title | Speaker 2 | Title |
|---|---|---|---|---|---|---|---|---|
| S02E01 chair/co-chair: Marian Waterman Vidhya Munnamalai | Thursday September 16 2021, 15:00 | https://uci.zoom.us/j/97301529578?pwd=S3hGVkd6ZW1tNS9vS1l2eXMrQktDdz09 | Friday September 17 2021, 0:00 | https://uci.zoom.us/j/97301529578?pwd=S3hGVkd6ZW1tNS9vS1l2eXMrQktDdz09 | Roel Nusse, Stanford University | If Wnt is a proliferative signal, why do cells need other signals in addition to Wnt to enter the cell cycle ? | Ben Myers, Asst Prof, U. Utah | “Pseudosubstrate Inhibition: A Shared Biochemical Mechanism underlying Hedgehog and Wnt Signal Transduction?” |
| S02E02 chair/co-chair: Liz Vincan Osvaldo Contreras | Thursday October 7 2021, 8:00 | https://nus-sg.zoom.us/j/83411118904?pwd=TDdGSWVac21jL0lLcDdBcXc2alNtZz09 | Thursday October 7 2021, 23:00 | https://nus-sg.zoom.us/j/82091682865?pwd=aExQYnFBdmN2bUYvcW1Xckx2K3FSZz09 | David Virshup, Duke-NUS, Singapore | Lessons from PORCN inhibitors | Kaj Kamstra, Postdoc in A. Tups lab, University of Otago, New Zealand | The canonical Wnt pathway as a central mediator of glucose homeostasis in zebrafish |
| S02E03 chair/co-chair: Claudio Cantù Nuray Gunduz | Thursday October 28 2021, 7:00 | https://liu-se.zoom.us/j/66661656113 | Thursday October 28 2021, 16:00 | https://liu-se.zoom.us/j/66661656113 | Nicole Giebel, PhD student with Dr. Sergio Acebrón, Heidelberg University, Germany | Regulation of Wnt signalling by the deubiquitinase USP42 in adult stem cells and cancer | Bassem Hassan, Paris Brain Institute/INSERM, France | The Amyloid Precursor Protein is a conserved Wnt receptor |
| S02E04 chair/co-chair: Marian Waterman Henry Ho | Thursday November 18 2021, 15:00 | https://uci.zoom.us/j/7760522094 | Friday November 19 2021, 00:00 | https://uci.zoom.us/j/7760522094 | Ahmad Nabhan, postdoctoral fellow, Genentech | Dissecting and manipulating lung alveolar regeneration with frizzled agonists | Sathya Srinivasan, post-doctoral fellow with Henry Ho, University of California, Davis | Wnt5a-Ror signaling regulates cell migration and contractility via RhoA-Myosin-Actin axis |
| S02E05 chair/co-chair: David Virshup Liz Vincan | Thursday December 9 2021, 8:00 | https://nus-sg.zoom.us/j/81050710556passcode 332926 | Thursday December 9 2021, 23:00 | https://nus-sg.zoom.us/j/81884024547 passcode 892651 | Yiwei Li, Huazhong University of Science and Technology, China | Molecular crowding as a mechanoregulator of intestinal organoid growth via stabilizing LRP6 signalosome | Kristen S. Barratt, PD with Ruth Arkell, ANU, Canberra, Australia | ZIC3 Inhibition of Canonical WNT Signalling Controls Endoderm Formation To Ensure Left Right Heart Development |
| S02E06 chair/co-chair: Claudio Cantù Nuray Gunduz | Thursday January 13 2022, 8:00 | https://liu-se.zoom.us/j/65095877640 | Thursday January 13 2022, 17:00 | https://liu-se.zoom.us/j/65095877640 | Dustin Flanagan, postdoc with Owen Sansom, CRUK Beatson Institute, Glasgow, UK | Notum is deployed by Apc-mutant cells to rule the intestinal crypt | Yorick van de Grift, PhD student with Renée van Amerongen, University of Amsterdam, the Netherlands | A conserved distal chromatin hub controls Wnt4 gene expression in the mammary gland |
SCHEDULE S01
| Spring Session #1 (UTC time) | ZOOM LINK Session #1 | Spring Session #2 (UTC time) | ZOOM LINK Session #2 | Speaker 1 | Title | Speaker 2 | Title |
| Thursday, April 8, 2021, 8:00:00 AM | Thursday, April 8, 2021, 11:00:00 PM | Jia Yu, (PDF, David Virshup lab) | “Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion” | Kenta Kawasaki, (PDF, Toshi Sato lab) | “Wnt independency and morphology of colon tumors” | ||
| Thursday, April 22, 2021, 4:00:00 PM | Friday, April 23, 2021, 12:00:00 AM | Shreyasi Mukherjee (Graduate student, Zorn lab, Cincinnati Children’s Hospital Medical Center,) | SOX transcription factors direct TCF-independent Wnt/ß-catenin transcription. | Renee Conway, graduate student (Spence lab, University of Michigan) | “R-SPONDIN2+ Mesenchymal Cells Form the Bud Tip Progenitor Niche During Human Lung Development” | ||
| Thursday, May 6, 2021, 9:00:00 AM | Thursday, May 6, 2021, 4:00:00 PM | Karol Kaiser Bryja lab, Brno, Czech Republic current position: postdoc Doetsch lab in Basel | Title: Meis1-Wnt5a axis – The story of two choroid plexuses | Martti Maimets PDF, Jensen lab, BRIC and DanStem, University of Copenhagen, Denmark | Title: Mesenchymal-epithelial crosstalk shapes regional differences in the intestine via Wnt and Shh signalling | ||
| Thursday, May 20, 2021, 8:00:00 AM | Thursday, May 20, 2021, 11:00:00 PM | Kazuhiro Murakami, Kanazawa University (Nick Barker Lab) | A Genome-Scale CRISPR screen reveals novel factors regulating Wnt- dependent renewal of mouse gastric epithelial cells. | Chunhua Wan, Monash University (Ron Firestein lab) | “TOPFLASH does not light the way – Endogenous Wnt/β-catenin reporters identify therapeutic targets for Colorectal Cancer”. | ||
| Thursday, June 3, 2021, 4:00:00 PM | Friday, June 4, 2021, 12:00:00 AM | Myan Do, UCSD (Karl Willert lab) | “A FZD7-specific antibody-drug conjugate induces solid tumor regression in preclinical models”. | Vidhya Munnamalai Assistant Professor, The Jackson Laboratory | “Making sense from Incoherence: How the Wnt pathway segregates domains in the cochlea through an incoherent feedforward circuit.” | ||
| Thursday, June 17, 2021, 9:00:00 AM | Thursday, June 17, 2021, 4:00:00 PM | Tiemei Li, Postdoctoral fellow, Bienz Lab Cambridge UK | A tripartite complex between Axin and GSK3β bound to the cytoplasmic tail of LRP6 in Wnt signalosomes | Hazel Quinn, Walter Birchmeier lab, current affiliation Post-doctoral researcher Brisken Laboratory ISREC-EPFL Lausanne, Switzerland | YAP and β-Catenin Cooperate to Drive Oncogenesis in Basal-like Breast Cancer |
WntTalks 